Makoto Miyazaki Selected Research

Activating Transcription Factor 4

11/2018	The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP.
11/2016	Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells.
9/2013	PERK-eIF2α-ATF4-CHOP signaling contributes to TNFα-induced vascular calcification.
8/2012	Activating transcription factor 4 regulates stearate-induced vascular calcification.

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Makoto Miyazaki Research Topics

Disease

13	Vascular Calcification 01/2022 - 06/2010
12	Neoplasms (Cancer) 01/2022 - 02/2003
12	Obesity 01/2010 - 02/2003
9	Atherosclerosis 01/2018 - 11/2004
9	Insulin Resistance 01/2011 - 08/2002
8	Inflammation (Inflammations) 11/2020 - 02/2008
7	Chronic Renal Insufficiency 01/2022 - 06/2010
4	Breast Neoplasms (Breast Cancer) 10/2018 - 12/2013
4	Atherosclerotic Plaque (Atheroma) 01/2014 - 07/2010
3	Dyslipidemias (Dyslipidemia) 07/2022 - 06/2006
3	Drug-Related Side Effects and Adverse Reactions 04/2020 - 01/2020
3	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2020 - 03/2019
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 12/2013
3	Cardiovascular Diseases (Cardiovascular Disease) 06/2014 - 02/2003
3	Body Weight (Weight, Body) 03/2009 - 12/2003
3	Fatty Liver 02/2009 - 02/2004
3	Hypertriglyceridemia 02/2009 - 11/2002
2	Type 2 Diabetes Mellitus (MODY) 07/2022 - 10/2005
2	Carcinoma (Carcinomatosis) 01/2022 - 08/2021
2	Fibrosis (Cirrhosis) 11/2020 - 08/2014
2	Necrosis 01/2020 - 01/2018
2	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 01/2018
2	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 01/2018
2	Proteinuria 01/2019 - 05/2012
2	Kidney Diseases (Kidney Disease) 01/2019 - 10/2016
2	Hypoxia (Hypoxemia) 10/2018 - 01/2017
2	Diabetic Nephropathies (Diabetic Nephropathy) 10/2016 - 05/2012
2	Dehydration (Water Stress) 10/2016 - 08/2014
2	Hyperlipidemias (Hyperlipidemia) 01/2016 - 11/2002
2	Wounds and Injuries (Trauma) 11/2012 - 11/2012
2	Weight Loss (Weight Reduction) 03/2009 - 07/2002
2	Hypoglycemia (Reactive Hypoglycemia) 12/2007 - 09/2004
2	Hypercholesterolemia 12/2006 - 05/2005
2	Hyperinsulinism (Hyperinsulinemia) 07/2006 - 02/2004
2	Heart Failure 12/2004 - 12/2003
1	Non-alcoholic Fatty Liver Disease 07/2022
1	Hypertension (High Blood Pressure) 07/2022
1	Mumps 11/2021
1	Glomerulonephritis 01/2021

Drug/Important Bio-Agent (IBA)

13	Stearoyl-CoA DesaturaseIBA 09/2020 - 11/2002
8	Apolipoproteins E (ApoE)IBA 01/2016 - 02/2009
7	LipidsIBA 07/2022 - 03/2005
7	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 12/2006
6	Pharmaceutical PreparationsIBA 01/2021 - 01/2017
6	Fatty Acids (Saturated Fatty Acids)IBA 09/2020 - 06/2008
6	LeptinIBA 08/2010 - 07/2002
6	stearoyl-coenzyme A (stearoyl-CoA)IBA 01/2010 - 07/2002
5	EnzymesIBA 05/2020 - 03/2004
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 06/2014
5	CholesterolIBA 01/2016 - 12/2011
4	Glucose (Dextrose)FDA LinkGeneric 07/2022 - 09/2004
4	Deoxycholic Acid (Sodium Deoxycholate)IBA 01/2022 - 01/2018
4	Monounsaturated Fatty AcidsIBA 09/2020 - 02/2003
4	Activating Transcription Factor 4IBA 11/2018 - 08/2012
4	Lipoproteins (Lipoprotein)IBA 01/2018 - 12/2006
4	Triglycerides (Triacylglycerol)IBA 08/2010 - 11/2002
4	Oleic Acid (Oleate)IBA 01/2010 - 09/2004
3	suvorexantIBA 01/2020 - 03/2019
3	Cisplatin (Platino)FDA LinkGeneric 01/2020 - 11/2012
3	LDL Receptors (LDL Receptor)IBA 01/2018 - 12/2011
3	StearatesIBA 08/2012 - 01/2007
3	Insulin (Novolin)FDA Link 01/2011 - 07/2006
3	CarbohydratesIBA 02/2009 - 12/2006
2	VaccinesIBA 11/2021 - 01/2018
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 08/2021 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2019 - 08/2002
2	Immunoglobulin G (IgG)IBA 01/2019 - 12/2018
2	AlbuminsIBA 01/2019 - 10/2018
2	Transcription Factor CHOPIBA 11/2018 - 09/2013
2	6-ethyl-24-norcholane-3,7,23-triol-23 sulfateIBA 01/2018 - 01/2014
2	Phosphates (Orthophosphate)IBA 01/2018 - 11/2016
2	CreatinineIBA 01/2018 - 08/2014
2	Phosphotransferases (Kinase)IBA 01/2017 - 09/2013
2	Protein Kinases (Protein Kinase)IBA 01/2017 - 09/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 01/2017
2	FructoseIBA 10/2016 - 08/2014
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2014 - 06/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2013 - 01/2010
2	Liver X ReceptorsIBA 01/2013 - 09/2006
2	HDL CholesterolIBA 12/2012 - 09/2006
2	ApolipoproteinsIBA 06/2010 - 12/2006
2	LipopolysaccharidesIBA 01/2010 - 02/2008
2	SterolsIBA 02/2009 - 05/2005
2	ElementsIBA 02/2009 - 05/2005
2	Sterol Regulatory Element Binding Protein 1IBA 07/2006 - 05/2005
2	Carvedilol (Coreg)FDA LinkGeneric 12/2004 - 12/2003
2	Phospholipids (Phosphatides)FDA LinkGeneric 03/2004 - 02/2003
1	SodiumIBA 07/2022
1	ThiazolidinesIBA 07/2022
1	Hypoglycemic Agents (Hypoglycemics)IBA 07/2022
1	Angiotensin Receptor AntagonistsIBA 07/2022
1	Antihypertensive Agents (Antihypertensives)IBA 07/2022
1	Fibric Acids (Fibrates)IBA 07/2022
1	IntegrinsIBA 01/2022
1	Tyrosine (L-Tyrosine)FDA Link 08/2021
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021
1	AntithrombinsIBA 01/2021

Therapy/Procedure

6	Therapeutics 11/2020 - 05/2012
2	Drug Therapy (Chemotherapy) 01/2018 - 12/2013
1	Drug Prescriptions 07/2022